Adams, a school vice principal, have built a close-knit, loving family with Stef's biological son from a previous marriage, Brandon, and their adopted twins, Mariana and Jesus. Their lives are disrupted in unexpected ways when Lena meets Callie, a hardened teen with an abusive past who has spent her life in and out of foster homes. Lena and Stef welcome Callie and her brother, Jude, into their home thinking it's just for a few weeks, until a more permanent placement can be found. But life has something else in store for the Fosters.
The series stars Teri Polo as Stef, Sherri Saum as Lena, Noah Centineo as Jesus, Hayden Byerly as Jude, David Lambert as Brandon, Maia Mitchell as Callie, Danny Nucci as Mike, and Cierra Ramirez as Mariana.